Open Innovation Drug Discovery

OIDD Synthesis

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The OIDD Synthesis program offers participating investigators the opportunity to synthesize compounds remotely in Lilly's Automated Synthesis Laboratory (ASL). The ASL provides synthetic chemists the ability to explore novel synthetic approaches, improve reaction efficiency, and test the feasibility of synthetic routes to maximize the yield of targeted compounds.

The OIDD Synthesis submission process involves four steps: Compound Library Proposal, Evaluation, Selection and Implementation.

Compound Library Proposal

Participating investigators can design libraries of related compounds to be synthesized in the ASL. These compounds should ideally explore either new chemistry or provide access to unique structural motifs.

Evaluation

The structures in each library are evaluated using in silico tools that look for such things as drug-like properties and similarity to prior submissions. Evaluation is automated without disclosure of any structural details to Lilly scientists.

Selection

Libraries that pass the in silico evaluation are eligible for consideration as an OIDD Synthesis Collaboration. A member of the OIDD team will reach out to the investigator to conduct a synthetic feasibility assessment.

Implementation

Once a separate Automated Synthesis Laboratory Agreement has been signed, the investigator or his/her designee (graduate student, post-doc, research associate) will participate in an orientation for the ASL. Once trained, that investigator will be connected with Lilly scientists in the lab who will implement the design and carry out the reactions the investigator directs. This gives the investigator the opportunity to orchestrate his or her own synthesis activities remotely.

Newly synthesized materials are then split between the investigator and Lilly. Each partner may subsequently use the materials for his or her own research.