Open Innovation Drug Discovery

Emerging Biology

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The OIDD Emerging Biology program offers participating investigators access to a variety of Lilly Biology Interrogation Compound (BIC) Cassettes to investigate biology hypotheses and aide in the development of novel biological assays having potential therapeutic relevance.

We provide you the chemical matter to interrogate your novel biological hypotheses, and you share with Lilly the biological results you generate with a BIC Cassette. Based on the data generated, Lilly will disclose the structures of potentially interesting compounds to enable further investigation and publication. Findings may form the basis for collaboration and broader access to additional related compounds from the Lilly collection.

The Lilly BIC Cassettes

These are Lilly-assembled, chemical libraries designed to facilitate an efficient exploration of emerging biological science. They comprise diverse chemical compounds selected from subsets of the Lilly proprietary compound collection, with unique characteristics that may help identify new breakthroughs in key areas of unmet medical needs.

The Lilly BIC Cassettes do not overlap with commercially available libraries but include a representative sampling of Lilly's proprietary compound collection. Most BIC compounds are accompanied by several analogs in order to provide immediate information about the structure-activity relationship (SAR) and potential biological activity of interest.

The BIC Cassettes come pre-plated and ready for screening. The cassettes can be supplied at volumes tailored to suit various screening and assay platforms. Access to these collections of compounds are available to you through the Lilly OIDD program.