Open Innovation Drug Discovery

Publishing Your Work

We encourage you to publish your results from screening of your compounds in OIDD biological assays. We want to know about your successes and help provide any additional information or guidance you need to prepare a publication. Contact the openinnovation@lilly.com team today to share your plans.

If you decide to publish, please acknowledge our program using the following language:

"OIDD screening data supplied courtesy of Eli Lilly and Company—used with Lilly's permission. To learn more about the Lilly Open Innovation Drug Discovery program, please visit the program website at https://openinnovation.lilly.com (last accessed on dd-mm-yyyy)."

Recently Published Work by OIDD Participant Scientists

Catalytic asymmetric hetero-Diels–Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives
H. Cui, P. Chouthaiwale, F. Yin, F. Tanaka; Org. Biomol. Chem., 2016, 14(5): 1777-1783.

Tetracyclic dihydronaphthalene derivatives via gold-catalyzed aminative homodimerization of ortho-alkynylbenzaldehydes
A. Ruch, F. Kong, V. Nesterova, L. Slaughter; Chem. Commun., 2016, 52(98): 14133-14136.

Diversification of ortho-Fused Cycloocta-2,5-dien-1-one Cores and Eight- to Six-Ring Conversion by σ Bond C-C Cleavage
L. Eccleshare, L. Lozada-Rodriguez, P. Cooper, L. Burroughs, J. Ritchie, W. Lewis, S. Woodward; Chem. Eur. J., 2016, 22(35): 12542–12547.

Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade
R.A. Craig II, J.L. Roizen, R.C. Smith, A.C. Jones, S.C. Virgila, B.M. Stoltz; Chemical Science, 2016.

Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy
O.G. Chepurny, C.A. Leech, M. Tomanik, M.C. DiPoto, H. Li, X. Han, Q. Meng, R.N. Cooney, J. Wu, G.G. Holz; Scientific Reports, 2016, 6: 1-16.

Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds
H.Y. Ebrahim, K.A. El Sayed; Mar Drugs, 2016, 14(3): 57.

Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro [1,2,4]triazolo[4,3-α]- and [1,5-α]pyridine cores
A. Mishchuk, N. Shtil, M. Poberezhnyk, K. Nazarenko, T. Savchenko, A. Tolmachev, M. Krasavin; Tetrahedron Letters, 2016, 57(9): 1056–1059.

Rescuing Abandoned Molecules as Nav1.7 and PCSK9 Inhibitors
G. Amico, L. Basile, G. Romeo, L. Salerno, M.N. Modica, M.A. Siracusa, A. Marrazzo, V. Pittalà, S. Guccione; JAMPS, 2016, 5(2): 1-10.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays
J.A. Lee, P. Shinn, S. Jaken, S. Oliver, F.S. Willard, S. Heidler, R.B. Peery, J. Oler, S. Chu, N. Southall, T.S. Dexheimer, J. Smallwood, R. Huang, R. Guha, A. Jadhav, K. Cox, C.P. Austin, A. Simeonov, G.S. Sittampalam, S. Husain, N. Franklin, D.J. Wild, J.J. Yang, J.J. Sutherland, C.J. Thomas; PLoS One, 2015, 10(7): 1-21.

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-α] [1,3,5]triazin-5-amines
A.V. Dolzhenko, B.J. Tan, G.N. Chiu, W. Chui, A.V. Dolzhenko; Journal of Fluorine Chemistry, 2015, 175: 68-72.

Beyond Acid Strength in Zeolites: Soft Framework Counteranions for Stabilization of Carbocations on Zeolites and Its Implication in Organic Synthesis
J.R. Cabrero-Antonino, A. Leyva-Pérez, A. Corma; Angew. Chem., 2015, 127(19): 5750-5753.

Synthesis of novel pleuromutilin derivatives. Part 1: Preliminary studies of antituberculosis activity
Y. Dong, Z. Meng, Y. Mi, C. Zhang, Z. Cui , P. Wang, Z. Xu; Bioorganic & Medicinal Chemistry Letters, 2015, 25(8): 1799-1803.

4-Amino-substituted pyrazolo[1,5-α][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
F. Lima, A.V. Dolzhenko; Tetrahedron Letters, 2014, 55(49): 6684–6688.

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA
R. Román, A. Navarro, D. Wodka, M. Alvim-Gaston, S. Husain, N. Franklin, A. Simón-Fuentes, S. Fustero; Org. Process Res. Dev., 2014, 8(8): 1027-1036.

Discovery of azaisoerianin derivatives as potential antitumors agents
M.A. Soussi , O. Provot, G. Bernadat, J. Bignon, J. Wdzieczak-Bakala, D. Desravines, J. Dubois, J. Brion, S. Messaoudi, M. Alami; European Journal of Medicinal Chemistry, 2014, 78: 178-189.

The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure–activity relationships
M.B. Shaghafi, D.G. Barrett, F.S. Willard, L.E. Overman; Bioorganic & Medicinal Chemistry Letters, 2014, 24(4): 1031-1036.

Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells
A.A. Sallam, N.B. Ayoub, A.I. Foudah, C.R. Gissendanner, S.A. Meyer, K.A. El Sayed; European Journal of Medicinal Chemistry, 2013, 70: 594-606.

Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use
J. Wu, WO 2013177241 A1, 2013.

(-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers
A.Y. Elnagar, P.W. Sylvester, K.A. El Sayed; Planta Med., 2011, 77(10): 1013-1019.